Higher Plasma Concentration of Food-Specific Antibodies in Persons With Autistic Disorder in Comparison to Their Siblings

Vladimir Trajkovski, Aleksandar Petlichkovski, Olivija Efinska-Mladenovska,
Dejan Trajkov, Todor Arsov, Ana Strezova, Ljubomir Ajdinski, Mirko Spiroski

Article Information
Volume: 23 issue: 3, page(s): 176-185
Article first published online: June 11, 2008; Issue published: September 1, 2008

https://doi.org/10.1177/1088357608320413

Abstract

Specific IgA, IgG, and IgE antibodies to food antigens in 35 participants with autistic disorder and 21 of their siblings in the Republic of Macedonia were examined. Statistically significant higher plasma concentration of IgA antibodies against alpha-lactalbumin, beta-lactoglobulin, casein, and gliadin were found in the children with autistic disorder. Plasma concentrations of IgG antibodies against alpha-lactalbumin, beta-lactoglobulin, and casein in participants with autistic disorder were significantly higher. IgE-specific antibodies (alpha-lactalbumin, beta-lactoglobulin, casein, and gluten), as well as plasma concentration of total IgE, also were statistically significantly higher in the participants with autistic disorder. Gender differences were found for select IgA, IgG, and IgE (but not for total IgE) food-specific antibodies (kU/L) in the participants with autistic disorder and their siblings.

Keywords autistic disorder, diet, family

Source: http://journals.sagepub.com