Showing posts with label intellectual disability. Show all posts
Showing posts with label intellectual disability. Show all posts

Thursday, June 19, 2025

CUPID Scientific Webinar - 19.06.2025

Respected colleagues, ladies and gentlemen welcome to the Scientific webinar entitled: “Towards Equity in Health Care - Updates from the CUPID COST Action”.

Today, we gather as researchers, clinicians, policymakers, and advocates to explore how we can advance equity in healthcare for individuals with intellectual disabilities.
Over the past 2 and a half years, the CUPID network has been dedicated to identifying and addressing key disparities in cancer prevention, diagnosis, and treatment within the intellectual disability community. As we approach new milestones, we reflect on the impactful research, collaborative efforts, and policy recommendations that are shaping a more inclusive healthcare system.
Health equity remains a fundamental priority. A growing body of evidence shows that individuals with intellectual disabilities face significant challenges in accessing timely and adequate healthcare. The underdiagnosis of cancer, lower survival rates, and systemic barriers in medical systems highlight the urgent need for tailored interventions. Today’s webinar will provide crucial updates on CUPID’s ongoing work, reinforcing our commitment to ensuring that no individual is left behind.

Our objectives remain clear:

- Strengthening research collaborations across Europe and beyond.

- Enhancing knowledge-sharing on best practices in cancer prevention and care.

- Encouraging interdisciplinary approaches to improve healthcare accessibility for individuals with intellectual disabilities.

Throughout this webinar, we will hear from young research experts on topics such as:

- Recent findings on cancer prevalence in individuals with intellectual disabilities.

- Strategies for improving screening uptake.

- Policy recommendations for equitable healthcare access. Let’s make this a meaningful and productive discussion. Each presentation will last approximately 8–10 minutes, followed by a discussion session at the end where we welcome your questions and comments.

A study on cancer prevalence in individuals with profound and multiple disabilities (PMD) found that while overall cancer risk may be lower due to shorter life expectancy, certain cancers—particularly digestive tract cancers—occur more frequently and at younger ages in this population. This study reinforce the urgent need for improved cancer screening, diagnosis, and treatment strategies tailored to individuals with IDD.

WG4 Leader

Friday, February 28, 2020

Nuclear receptor corepressors in intellectual disability and autism

 2020 Feb 7. doi: 10.1038/s41380-020-0667-y. [Epub ahead of print]

Kong Y1,2Zhou W2Sun Z3.

1. Department of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing, China.

2. Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA.
         3.Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA. 


Abstract

Autism spectrum disorder (ASD) is characterized by neurocognitive dysfunctions, such as impaired social interaction and language learning. Gene-environment interactions have a pivotal role in ASD pathogenesis. Nuclear receptor corepressors (NCORs) are transcription co-regulators physically associated with histone deacetylases (HDACs) and many known players in ASD etiology such as transducin β-like 1 X-linked receptor 1 and methyl-CpG binding protein 2. The epigenome-modifying NCOR complex is sensitive to many ASD risk factors, including HDAC inhibitor valproic acid and a variety of endocrine factors, xenobiotic chemicals, or metabolites that can directly bind to multiple nuclear receptors. Here, we review recent studies of NCORs in neurocognition using animal models and human genetics approaches. We discuss functional interplays between NCORs and other known players in ASD etiology. It is conceivable that the NCOR complex may bridge the in utero environmental risk factors of ASD with epigenetic remodeling and can serve as a converging point for many gene-environment interactions in the pathogenesis of ASD and intellectual disability.